gene expression profile – Communicable Diseases Research

Identification of the Hub Genes and the Signaling Pathways in Human iPSC-Cardiomyocytes Infected by SARS-CoV-2

Article

Published on 2022-12-012022-11-16
Journal: Biochemical Genetics
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronaviruses

Article

Published on 2022-11-052022-11-15
Journal: Scientific Reports
[Category] SARS, 신약개발, 치료제,

Hepatitis B virus (HBV) codon adapts well to the gene expression profile of liver cancer: an evolutionary explanation for HBV’s oncogenic role

Article

Published on 2022-11-012022-11-16
Journal: Journal of microbiology (Seoul, Korea)
[Category] B형 간염, COVID19(2023년), SARS, 유전자 메커니즘,

HLA-C dysregulation as a possible mechanism of immune evasion in SARS-CoV-2 and other RNA-virus infections

Article

Published on 2022-10-172022-11-16
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] alteration Analysis antigenic Cell cells changes in co-morbidities COVID-19 COVID-19 patient COVID-19 patients decrease DNA DNA methylation dysregulation enhancer enhancer transcriptional regulation evade expression Gene Expression gene expression profile genes encoding healthy controls HLA-C Host immune evasion immune response immune system implicated Infection inhibit Intervention involved mechanism memory response Methylation modify overlap Pathogens presenting Prognosis Prognostic marker Protein respiratory infection SARS-CoV-2 shown significantly symptomatic and asymptomatic symptomatic and asymptomatic COVID-19 T-cell therapeutic target transcriptional upper airway upper airways cells. viral antigens virus
[DOI] 10.3389/fimmu.2022.1011829 PMC 바로가기

Pin-Pointing the Key Hubs in the IFN-γ Pathway Responding to SARS-CoV-2 Infection

Article

Published on 2022-09-302022-11-16
Journal: Viruses
[Category] SARS, 치료법,

RNA sequence analysis of nasopharyngeal swabs from asymptomatic and mildly symptomatic patients with COVID-19

Research article

Published on 2022-09-012022-10-05
Journal: International Journal of Infectious Diseases
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] Analysis Asymptomatic autophagy Bacterial Cell changes in Coinfection complement COVID-19 Differential gene expression disease severity dysregulation Epigenetic gene expression profile Gene ontology group identify in both group investigated involved mildly symptomatic patient Modification modulation mRNA Nasopharyngeal swab objective outcome Patient patients performed profile progression proportion reduction in Result retrieved RNA RNA sequence SARS-CoV-2 SARS-COV-2 infection Sequence analysis Sequencing Streptococcus pneumoniae symptomatic symptomatic individuals Symptomatic patients the disease transcriptomic transcriptomics translation Transport upregulation Viral genome assembly viral variant with COVID-19
[DOI] 10.1016/j.ijid.2022.06.035 [Article Type] Research article

Discovering common pathogenetic processes between COVID-19 and sepsis by bioinformatics and system biology approach

Article

Published on 2022-08-312022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] acute respiratory syndrome addition Analysis approach bioinformatics Biomarker Blood caused clinical manifestations Clinical practice Coagulopathy Corona Coronavirus-2 COVID-19 Critically ill Critically ill patient Cytokine storm database DEGs demonstrated diagnostic differentially expressed differentially expressed gene differentially expressed gene (DEG) disease drug molecule enrichment analysis functional functional enrichment Gene Expression Omnibus gene expression profile Gene ontology gene regulatory network genetic link genetic mechanism GEO high mortality rate hub gene hypercoagulable Inflammatory response Interaction ITGAM molecular docking molecular mechanism multiple organ dysfunction neutrophil dysfunction pandemic Pathogenesis pathogenesis of COVID-19 pathway potential therapeutic agents progesterone protein-protein interaction Protein–protein interaction protein–protein interaction (PPI) receptor Regulatory Research respiratory infectious disease resulting risk SARS-CoV-2 screened Sepsis sepsis patient sepsis. Septic shock severe COVID-19 signaling pathway similarity Spread syndrome System biology Systems biology Treatment were used with COVID-19
[DOI] 10.3389/fimmu.2022.975848 PMC 바로가기

Identifying novel host-based diagnostic biomarker panels for COVID-19: a whole-blood/nasopharyngeal transcriptome meta-analysis

COVID-19에 대한 새로운 호스트 기반 진단 바이오마커 패널 식별: 전혈/비인두 전사체 메타 분석

Meta-Analysis

Published on 2022-08-032022-09-11
Journal: Molecular Medicine
[Category] SARS, 바이오마커, 유전자 메커니즘, 치료기술,

[키워드] Accuracy acute respiratory illness acute respiratory illnesses analysis applied ARI bioinformatics Biomarker Blood Cell cell cycle Characteristics Combination complementary controls COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients COVID-19 sample cross cytokine cytokine production Data integration dataset Defense detect diagnose diagnostic diagnostic biomarker Diagnostic biomarkers Diseases eight enhancement feature gene expression profile Gene ontology HCs healthy control healthy controls Host host gene host response identifying Immune cell improvement Improvements independent indicated induce Infection Inflammatory interferon introduced lack machine learning algorithm Machine learning algorithms marker Meta-analysis nasopharyngeal Nasopharyngeal swab Ontology Pathogenesis pathway pathway enrichment patients with COVID-19 proportion Random forest respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis selected swab sample System Systems biology Transcriptome upregulation Viral virus Whole blood whole blood.
[DOI] 10.1186/s10020-022-00513-5 PMC 바로가기 [Article Type] Meta-Analysis

Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 infection and primary Sjogren’s syndrome

COVID-19 감염 및 원발성 쇼그렌 증후군에 대한 잠재적인 일반적인 병원성 메커니즘의 생물정보학 분석

Article

Published on 2022-07-262022-09-11
Journal: Frontiers in Immunology
[Category] 유전자 메커니즘,

[키워드] Analysis analysis CDCA2 cellular component cellular components CMPK2 COVID-19 COVID-19 infection cytoHubba database DEGs diagnostic Diagnostic markers differentially expressed differentially expressed gene Differentially expressed genes downloaded Evidence functional annotation Gene Expression Omnibus gene expression profile Gene expression profiles gene regulatory network General population Genes GEO HERC5 hub genes Ifi44 IFI44L IFIT1 IFIT2 IFIT3 marker mechanism metabolic pathway metabolic pathways molecular mechanism molecular mechanisms MX1 participated Pathogenesis pathogenic mechanism pathway Patient performed PPI Prevalence primary Sjogren’s syndrome. progression protein-protein interaction regulatory network reveal RRM2 selected significantly higher Sjögren’s syndrome subsequent analyses syndrome TOP2A transcription factor TYMS
[DOI] 10.3389/fimmu.2022.938837 PMC 바로가기 [Article Type] Article

Anti-inflammatory response of cardamom extract and prediction of therapeutic window in COVID-19 patients by assessing inflammatory markers using RT-PCR

RT-PCR을 사용한 염증 마커를 평가함으로써 COVID-19 환자에서 카 다몬 추출물의 항 염증 반응 및 치료 창의 예측

Article

Published on 2022-06-012022-08-31
Journal: Inflammopharmacology
[Category] COVID19(2023년), MERS, SARS, 진단, 치료제,

[키워드] addition alternative Anti-inflammatory anti-inflammatory action anti-inflammatory response Anti-viral association attending physician Awareness breathlessness can not Cardamom Clinical improvement Clinical practice clinician control group cough Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 symptom COVID-19 symptoms CRP Ct values cycle threshold cytokine Cytokine storm dawn Diagnostic method diagnostic test diagnostic tests disease Disease progression dosage dose effective elevated end point enrolled Fever FORTE gene expression profile hospital IL-10 IL-6 India indicate Inflammation Inflammatory marker inflammatory markers inflammatory parameter intake Intervention lack LDH majority material molecular diagnostics morbidity morbidity and mortality multiplex negativity normalized onset of symptom outcome parameter Patient patients PCR test performed popularity potentiality predict Prednisolone prevalent Prognosis Prognosis. protein level provide reason for reducing reported RT-PCR RT-PCR analysis RT-PCR assay RT-PCR test SARS-CoV-2 SARS-CoV-2 RT-PCR SARS-CoV-2 RT-PCR test serum Serum IL-6 sore throat Standard of care standard treatment Steroids Symptom Tablet tested the cytokine storm the patient therapeutic window time TNF- α Treatment treatment arm treatment group were given worsening
[DOI] 10.1007/s10787-022-00951-x PMC 바로가기 [Article Type] Article